Issue 90, 2025
From the journal:

Chemical Communications

The synthesis of [18F]SynVesT-1 and [18F]SynVesT-2 from enantioenriched boronic esters

Marong Qin,a   Pawan Mishra,a   Jasmine Hind, ORCID logo a   Ian. A. Fallis ORCID logo a  and  Matthew Tredwell ORCID logo *ab  

* Corresponding authors

a School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff CF10 3AT, UK
E-mail: tredwellm@cardiff.ac.uk

b Wales Research and Diagnostic PET Imaging Centre, Cardiff University, University Hospital of Wales, Heath Park, Cardiff CF14 4XN, UK

Abstract

Enantioenriched [18F]SynVesT-1 and [18F]SynVesT-2 are prepared from the corresponding enantioenriched arylboronic esters and [18F]fluoride mediated by (Py)4Cu(OTf)2. The 18F-reaction is optimised on an automated synthesiser to produce multi-GBq quantities of both radiotracers to support (pre)clinical imaging.

Graphical abstract: The synthesis of [18F]SynVesT-1 and [18F]SynVesT-2 from enantioenriched boronic esters

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Article information

DOI
https://doi.org/10.1039/D5CC05507E
Article type
Communication
Submitted
24 Sep 2025
Accepted
08 Oct 2025
First published
10 Oct 2025
This article is Open Access
Creative Commons BY license

Chem. Commun., 2025,61, 17689-17692

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The synthesis of [18F]SynVesT-1 and [18F]SynVesT-2 from enantioenriched boronic esters

M. Qin, P. Mishra, J. Hind, Ian. A. Fallis and M. Tredwell, Chem. Commun., 2025, 61, 17689 DOI: 10.1039/D5CC05507E

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