Mechanochemically controllable synthesis of mono- or di-alkenylated indolizines

Abstract

We report the synthesis of a series of alkylated indolizine derivatives from indolizine and p-QMs under ball-milling conditions. This method offers a controllable approach to synthesize mono- or di-alkenylated indolizines through modulation of substrate ratios, acid additives, and oxidant types. This procedure is solvent-free and operationally simple, and exhibits broad substrate tolerance, high conversion efficiency, and excellent scalability, making it both practical and versatile.