TMO2 – a novel non-aqueous source of hydrogen peroxide

Abstract

Oxidation is a linchpin of the chemical industry, used in the manufacture of ∼60% of all products and intermediates with an associated global value estimated at USD 20–40 billion. Hydrogen peroxide (H₂O₂) is the preferred green oxidant by virtue of outstanding atom economy and benign co-product (water), yet its routine delivery as dilute aqueous solutions imposes water-compatibility constraints, biphasic mass-transfer penalties, waste generation and costly separations. We report TMO₂, a non-aqueous, bench-stable source of H₂O₂ formed in the green, reusable solvent TMO, decoupling oxidant delivery from water. TMO₂ enables peroxide oxidations under homogeneous, organic conditions, obviating phase-transfer operations and reducing waste while avoiding hazardous peracids (Addible Ltd., TMO₂ International Patent Application No. PCT/EP2025/074472). Concept, preparation, and representative reactivity are described herein; full procedures and data are provided in the SI.