Additive-free synthesis of α-keton thiol esters via oxyacylthiolation of vinyl azides with thioacids and water

Abstract

An additive-free strategy has been developed for the synthesis of α-keton thiol esters through direct oxyacylthiolation of vinyl azides with thioacids and water. The C–S and CO bonds were formed in a one-pot operation via a radical reaction pathway. A number of α-keton thiol esters could be efficiently obtained in good yields with broad substrate scope and good functional group tolerance.