The synthesis of β-carboxyphospholes has been achieved via carboxylative desilylation of their β-TMS-substituted analogues in a CO2 atmosphere. The title carboxylic acids allow facile transformation into the respective acyl chloride, carboxamide, ester and anhydride, which are compatible with bioconjugation, while the integrity of the phosphole unit is maintained.
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K. Eichhorn, C. Bruhn and R. Pietschnig, Chem. Commun., 2025, 61, 17129 DOI: 10.1039/D5CC04850H
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