Issue 97, 2025
From the journal:

Chemical Communications

Transition-metal–free borylative functionalization of aryl fluorides with boron alkoxide in the presence of sodium dispersion

Shuichi Ikeda,a   Ukyo Ogi,a   Kentaro Okano ORCID logo a  and  Atsunori Mori ORCID logo *ab  

* Corresponding authors

a Department of Chemical Science and Engineering, Kobe University, 1-1 Rokkodai, Nada, Kobe 657-8501, Japan
E-mail: amori@kobe-u.ac.jp

b Research Center for Membrane and Film Technology, Kobe University, 1-1 Rokkodai, Nada, Kobe 657-8501, Japan

Abstract

Borylative functionlization of an aryl fluoride was performed using a transition-metal–free process with sodium dispersion (SD). The reaction of 4-fluorobiphenyl with boron alkoxide (iPrOBpin) in the presence of SD afforded the borylated product in up to 62% yield. The borylation reaction proceeded with several aryl fluorides in good to excellent yields.

Graphical abstract: Transition-metal–free borylative functionalization of aryl fluorides with boron alkoxide in the presence of sodium dispersion

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Article information

DOI
https://doi.org/10.1039/D5CC04739K
Article type
Communication
Submitted
16 Aug 2025
Accepted
21 Oct 2025
First published
24 Oct 2025

Chem. Commun., 2025,61, 19301-19304

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Transition-metal–free borylative functionalization of aryl fluorides with boron alkoxide in the presence of sodium dispersion

S. Ikeda, U. Ogi, K. Okano and A. Mori, Chem. Commun., 2025, 61, 19301 DOI: 10.1039/D5CC04739K

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