Synthesis of a highly strained deep cavitand

Abstract

Access to highly strained molecules remains a challenge. We report the synthesis of a bench-stable and highly strained (∼135 kcal mol⁻¹) deep cavitand (1). Synthesis of 1 follows a two-step protocol from known starting materials. The rigid structure of 1 contains four arch-shaped biphenyelenes with a large cavity (∼500 ų) to host fullerenes.