Catalytic α-C–H functionalization of carbonyl compounds via SET-induced formation of α-carbonyl radicals
Abstract
The catalytic α-functionalization of carbonyl compounds, via SET induced formation of α-carbonyl radicals, compares favorably with traditional electrophilic functionalization of enolates. The present review article, showcases an up-to-date progress on the catalytic functionalization of ketones and carboxylic acid equivalents, via single electron transfer (SET) induced formation of α-carbonyl radicals. Transition metal catalysed and photoredox-catalysed SET induced transformations of α-carbonyl radicals are primarily featured here.
- This article is part of the themed collection: The Functionalization of Unreactive Carbon-Hydrogen Bonds