Catalytic α-C–H functionalization of carbonyl compounds via SET-induced formation of α-carbonyl radicals

Abstract

The catalytic α-functionalization of carbonyl compounds, via SET induced formation of α-carbonyl radicals, compares favorably with traditional electrophilic functionalization of enolates. The present review article, showcases an up-to-date progress on the catalytic functionalization of ketones and carboxylic acid equivalents, via single electron transfer (SET) induced formation of α-carbonyl radicals. Transition metal catalysed and photoredox-catalysed SET induced transformations of α-carbonyl radicals are primarily featured here.

Article information

Article type
Feature Article
Submitted
09 Jul 2025
Accepted
11 Aug 2025
First published
13 Aug 2025

Chem. Commun., 2025, Accepted Manuscript

Catalytic α-C–H functionalization of carbonyl compounds via SET-induced formation of α-carbonyl radicals

A. Singh and S. Bhadra, Chem. Commun., 2025, Accepted Manuscript , DOI: 10.1039/D5CC03886C

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