Glycan-induced fluorescence enhancement using a molecular rotor–boronic acid conjugate

Mandana Oloub; Alen Koçak; Cihan Baydaroğlu; Amal K. Homer; Florian Telschow; Victor M. Loyo-Cruz; Sebastian Trunschke; Gaël M. Vos; Kevin Pagel; Michael Gradzielski; Ulrike Alexiev; Oliver Seitz

doi:10.1039/D5CC02827B

Glycan-induced fluorescence enhancement using a molecular rotor–boronic acid conjugate

Mandana Oloub,

^a Alen Koçak,

^a Cihan Baydaroğlu,^b Amal K. Homer,^a Florian Telschow,^c Victor M. Loyo-Cruz,

^c Sebastian Trunschke,^a Gaël M. Vos,

^d Kevin Pagel,

^d Michael Gradzielski,

^b Ulrike Alexiev

^c and Oliver Seitz

*^a

Author affiliations

* Corresponding authors

^a Institute of Chemistry, Humboldt-Universität zu Berlin, Brook-Taylor-Str. 2, 12489 Berlin, Germany
E-mail: oliver.seitz@chemie.hu-berlin.de

^b Institute of Chemistry, Technische Universität Berlin, Strasse des 17. Juni 124, 10623 Berlin, Germany

^c Institute of Physics, Freie Universität Berlin, Arnimallee 14, 14195 Berlin, Germany

^d Institute of Chemistry and Biochemistry, Freie Universität Berlin, Altensteinstrasse 23A, 14195 Berlin, Germany

Abstract

Fluorescent molecular rotors (FMRs) are known for their sensitivity to changes in viscosity and confinement. Here, we show that a boronic acid conjugate of the rotor dye CCVJ exhibits strong enhancements in fluorescence upon binding to complex glycans. Glycan-induced fluorescence enhancement (GIFE) operates at low and high viscosity.

Chemical Communications

Glycan-induced fluorescence enhancement using a molecular rotor–boronic acid conjugate

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Glycan-induced fluorescence enhancement using a molecular rotor–boronic acid conjugate

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