Palladium-catalyzed tandem cyclization reaction: access to isoxazoline-benzofuran bis-heterocycles

Abstract

A novel palladium-catalyzed carboetherification reaction of β,γ-unsaturated ketoxime with gem-dihaloolefin has been developed. This process offers an efficient route for the assembly of isoxazoline-linked benzofuran/indole bis-heterocycles in moderate to good yields. The scalability of the reaction and subsequent transformations of the products highlight the synthetic potential of this developed method.