Issue 62, 2025
From the journal:

Chemical Communications

Backbone cleavage of peptides and proteins via cysteine S-fluoroacetylation†

Yuya Matsumoto, ORCID logo a   Naoki Zenmyo,a   Shunsuke Watanabe,a   Kaori Sasaki-Tabata,a   Shohei Uchinomiya,a   Naoya Shindo ORCID logo a  and  Akio Ojida ORCID logo *a  

* Corresponding authors

a Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
E-mail: ojida@phar.kyushu-u.ac.jp

Abstract

S-Fluoroacetylation of cysteine residues enables efficient cleavage of main-chain amide bonds in peptides and proteins under neutral aqueous conditions.

Graphical abstract: Backbone cleavage of peptides and proteins via cysteine S-fluoroacetylation

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Article information

DOI
https://doi.org/10.1039/D5CC02215K
Article type
Communication
Submitted
08 May 2025
Accepted
23 Jun 2025
First published
02 Jul 2025
This article is Open Access
Creative Commons BY license

Chem. Commun., 2025,61, 11625-11628

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Backbone cleavage of peptides and proteins via cysteine S-fluoroacetylation

Y. Matsumoto, N. Zenmyo, S. Watanabe, K. Sasaki-Tabata, S. Uchinomiya, N. Shindo and A. Ojida, Chem. Commun., 2025, 61, 11625 DOI: 10.1039/D5CC02215K

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