Issue 56, 2025

Macrocyclic skeletal modification approach to the anti-trypanosomal macrolides, actinoallolides

Abstract

Herein, we report the construction of 16-membered macrocycles that were designed as intermediates toward the unified synthesis of actinoallolides. Key to our synthesis was the use of Mitsunobu macrocyclization, followed by a sequence of Birch reduction and oxidative C–C cleavage to edit the macrocycle.

Graphical abstract: Macrocyclic skeletal modification approach to the anti-trypanosomal macrolides, actinoallolides

Supplementary files

Article information

Article type
Communication
Submitted
05 Apr 2025
Accepted
30 May 2025
First published
09 Jun 2025
This article is Open Access
Creative Commons BY license

Chem. Commun., 2025,61, 10367-10370

Macrocyclic skeletal modification approach to the anti-trypanosomal macrolides, actinoallolides

G. Sennari, A. Watanabe, T. Ōno, J. Oshita, Y. Noguchi, T. Hirose and T. Sunazuka, Chem. Commun., 2025, 61, 10367 DOI: 10.1039/D5CC01915J

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