Peptide nucleic acid (PNA) clamps modified with 2-aminopyridine (M) nucleobase invaded double-stranded DNA under physiological salt conditions. In contrast, PNAs carrying common nucleobases could not fully invade DNA under these conditions. M-modified PNAs may overcome the problematic requirement for low salt concentration, a long-standing DNA invasion problem.
B. R. Tessier and E. Rozners, Chem. Commun., 2025, 61, 4070 DOI: 10.1039/D4CC06748G
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