Fast-response fiber organic electrochemical transistor with vertical channel design for electrophysiological monitoring

Abstract

Fiber organic electrochemical transistors (OECTs) hold significant promise for in vivo bio-signal amplification due to their minimally invasive and seamless integration with biological tissues. However, their use in monitoring rapid physiological changes, such as electrophysiological signals, has been constrained by slow response time, arising from their extensive channel dimensions. Here, we introduce a novel fiber OECT designed with a micro-scale vertical channel (F-vOECT) that substantially reduces the response time by an order of magnitude to 12 ms and achieves a maximum transconductance of 16 mS at zero gate bias, marking a substantial improvement over previous fiber OECTs. This compact and flexible fiber device demonstrates robust performance under cyclic switching, dynamic deformation and exhibits excellent biocompatibility. When subcutaneously implanted in rats, the F-vOECT enables stable, continuous electrocardiogram monitoring for 7 days, successfully identifying episodes of atrioventricular block. These capabilities illustrate its potential for clinical electrophysiological diagnostics. The design strategy of F-vOECT opens new avenues for developing fast-responsive fiber bioelectronic devices.