Issue 24, 2024

Dissolving microneedles for transdermal drug delivery in cancer immunotherapy

Abstract

Immunotherapy is an important approach in cancer treatment. Transdermal administration is emerging as a promising method for delivering immunotherapeutics. Dissolving microneedles are made mainly of soluble or biodegradable polymers and have garnered widespread attention due to their painlessness, safety, convenience, excellent drug loading capacity, and easy availability of various materials, making them an ideal transdermal delivery system. This review comprehensively summarized the preparation methods, materials, and applications of dissolving microneedles in cancer vaccines, immune checkpoint inhibitors, and adoptive cell therapy. Additionally, the challenges and perspectives associated with their future clinical translation are discussed.

Graphical abstract: Dissolving microneedles for transdermal drug delivery in cancer immunotherapy

Article information

Article type
Review Article
Submitted
29 Mar 2024
Accepted
22 May 2024
First published
10 Jun 2024

J. Mater. Chem. B, 2024,12, 5812-5822

Dissolving microneedles for transdermal drug delivery in cancer immunotherapy

M. Xiang, C. Yang, L. Zhang, S. Wang, Y. Ren and M. Gou, J. Mater. Chem. B, 2024, 12, 5812 DOI: 10.1039/D4TB00659C

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