Issue 24, 2024

Electrocatalytic FeFe2O4 embedded, spermine-imprinted polypyrrole (Fe/MIPpy) nanozymes for cancer diagnosis and prognosis

Abstract

Developing synthetic materials, with enzyme-like molecular recognition capabilities, as functional receptors in electronic or electrochemical devices for the timely diagnosis of major diseases is a great challenge. Herein, we present the development of Fe/MIPpy nanozymes, characterized as enzyme-like artificial receptors, for the precise and non-invasive monitoring of cancer biomarkers in aqueous solutions and human saliva. Through the integration of PVA-stabilized FeFe2O4 nanocrystals in a molecularly imprinted conducting polypyrrole matrix, the Fe/MIPpy nanozymes demonstrate 424 nA cm−2 nM−1 sensitivity and 220 pM detection limit. Charge-transfer mechanisms, Fe/MIPpy–spermine interactions, and the principle of spermine recognition are investigated by electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). The disposable Fe/MIPpy sensor operates wirelessly and offers rapid and remote quantification of spermine, making it a promising material for the development of cost-effective tools for non-invasive cancer diagnosis and prognosis.

Graphical abstract: Electrocatalytic FeFe2O4 embedded, spermine-imprinted polypyrrole (Fe/MIPpy) nanozymes for cancer diagnosis and prognosis

Supplementary files

Article information

Article type
Paper
Submitted
29 Jan 2024
Accepted
22 Apr 2024
First published
23 May 2024

J. Mater. Chem. B, 2024,12, 5898-5906

Electrocatalytic FeFe2O4 embedded, spermine-imprinted polypyrrole (Fe/MIPpy) nanozymes for cancer diagnosis and prognosis

I. Zaman, A. Liaqat, S. Athar, A. Mujahid and A. Afzal, J. Mater. Chem. B, 2024, 12, 5898 DOI: 10.1039/D4TB00190G

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