Issue 14, 2024

A portable smartphone platform utilizing dual-sensing signals for visual determination of semicarbazide in food samples

Abstract

Semicarbazide (SEM) is a metabolite of antibiotic nitrofurazone and a food contaminant in food production, showing potential carcinogenic, mutagenic, teratogenic, and toxic effects on human health. It is urgent to develop a highly efficient and sensitive assay for visual detection of SEM. In this paper, a pyrrolopyrrole cyanine fluorescent probe (PPCy-1) was reported for visualization and quantitative analysis of SEM through a chromophore reaction sensing mechanism for the first time. The probe towards SEM exhibited a fast response (10 min), a low detection limit (0.18 μM), high selectivity, and distinct dual ratiometric fluorescence turn-on and colorimetric modes. Its practicability was further verified by detecting SEM in meat, water, and honey samples with satisfactory recovery values. More importantly, a smartphone-assisted portable testing platform was constructed based on a PPCy-1-immobilized test paper or a polyamide thin film with a color scanning APP for real-time and on-site detection of SEM. This work provides low-cost, convenient, and rapid assays for visual SEM detection, which have potential applications in food safety monitoring.

Graphical abstract: A portable smartphone platform utilizing dual-sensing signals for visual determination of semicarbazide in food samples

Supplementary files

Article information

Article type
Paper
Submitted
01 Jan 2024
Accepted
09 Mar 2024
First published
11 Mar 2024

J. Mater. Chem. B, 2024,12, 3469-3480

A portable smartphone platform utilizing dual-sensing signals for visual determination of semicarbazide in food samples

L. Wang, B. Lai, X. Ran, H. Tang and D. Cao, J. Mater. Chem. B, 2024, 12, 3469 DOI: 10.1039/D4TB00001C

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