Issue 19, 2024

Tannic acid–poloxamer self-assembled nanoparticles for advanced atherosclerosis therapy by regulation of macrophage polarization

Abstract

Atherosclerosis (AS) is a significant contributor to cardiovascular events. Advanced AS is particularly concerning, as it leads to the formation of high-risk vulnerable plaques. Current treatments for AS focus on antithrombotic and lipid-lowering interventions, which are effective in treating early-stage AS. Recent studies have shown that macrophage polarization plays a crucial role in the development of AS. This study presents a new biomedical application of natural tannic acid as an anti-inflammatory nanoplatform for advanced AS. Tannic acid-poloxamer nanoparticles (TPNP) are fabricated through self-assembly of tannic acid (TA) and poloxamer. TPNP has the potential to provide effective treatment for advanced AS. According to in vitro studies, TPNP has been found to suppress the inflammatory response in lipopolysaccharide-stimulated macrophages by scavenging reactive oxygen species (ROS), downregulating the expression levels of inflammatory cytokines (such as interleukin-10 and tumor necrosis factor-α) and regulating polarization of macrophages. In vivo studies further reveal that TPNP can retard the development of advanced atherosclerotic plaques by reducing ROS production and promoting M2 macrophage polarization in the aorta of ApoE−/− mice. Overall, these findings suggest that TPNP could be used to develop natural multifunctional nanoplatforms for molecular therapy of AS and other inflammation-related diseases.

Graphical abstract: Tannic acid–poloxamer self-assembled nanoparticles for advanced atherosclerosis therapy by regulation of macrophage polarization

Supplementary files

Article information

Article type
Paper
Submitted
20 May 2023
Accepted
02 Apr 2024
First published
11 Apr 2024

J. Mater. Chem. B, 2024,12, 4708-4716

Tannic acid–poloxamer self-assembled nanoparticles for advanced atherosclerosis therapy by regulation of macrophage polarization

H. Wu, J. Sheng, Z. Wang, Z. Zu, K. Xiang, J. Qi, Z. Wang, G. Lu and L. Zhang, J. Mater. Chem. B, 2024, 12, 4708 DOI: 10.1039/D3TB01157G

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