Issue 24, 2024

Mechanochemical synthesis of aromatic ketones: pyrylium tetrafluoroborate mediated deaminative arylation of amides

Abstract

A new method has been introduced that is able to tackle the complexities of N–C(O) activation in amide moieties through utilization of pyrylium tetrafluoroborate in a mechanochemical setting, where amide bonds undergo activation and subsequent conversion to biaryl ketones. Due to the employment of a mechanochemical setting, the reaction conforms to green chemistry principles, offering an environmentally friendly approach to traditional amide derivatization techniques that rely on transition metals to achieve further functionalization.

Graphical abstract: Mechanochemical synthesis of aromatic ketones: pyrylium tetrafluoroborate mediated deaminative arylation of amides

Supplementary files

Article information

Article type
Edge Article
Submitted
06 Feb 2024
Accepted
30 Apr 2024
First published
14 May 2024
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2024,15, 9155-9163

Mechanochemical synthesis of aromatic ketones: pyrylium tetrafluoroborate mediated deaminative arylation of amides

S. Mkrtchyan, O. Shalimov, M. G. Garcia, J. Zapletal and V. O. Iaroshenko, Chem. Sci., 2024, 15, 9155 DOI: 10.1039/D4SC00904E

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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