Issue 15, 2024

Pendulum-like hemilability in a Ti-based frustrated Lewis Trio


We describe the first experimental example of a theoretically predicted Frustrated Lewis Trio (FLT). A tetradentate PNNP ligand is used to stabilise a highly electrophilic [TiCl3]+ fragment in a way that results in two equally long and frustrated Ti–P bonds. A combined experimental and computational approach revealed a distinct role of each Lewis basic phosphine in the heterolytic activation of chemical bonds. This dual functionality is characterised by a pendulum-like hemilability, where one of the phosphines acts as a nucleophile while the other serves as a hemilabile ligand that dynamically tunes the Ti–P distance as a function of the required electron density at the Ti centre.

Graphical abstract: Pendulum-like hemilability in a Ti-based frustrated Lewis Trio

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Article information

Article type
Edge Article
18 Dec 2023
08 Mar 2024
First published
08 Mar 2024
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2024,15, 5555-5563

Pendulum-like hemilability in a Ti-based frustrated Lewis Trio

E. Kounalis, D. van Tongeren, S. Melnikov, M. Lutz and D. L. J. Broere, Chem. Sci., 2024, 15, 5555 DOI: 10.1039/D3SC06789K

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