Issue 3, 2024

Dynamic covalent synthesis


Dynamic covalent synthesis aims to precisely control the assembly of simple building blocks linked by reversible covalent bonds to generate a single, structurally complex, product. In recent years, considerable progress in the programmability of dynamic covalent systems has enabled easy access to a broad range of assemblies, including macrocycles, shape-persistent cages, unconventional foldamers and mechanically-interlocked species (catenanes, knots, etc.). The reversibility of the covalent linkages can be either switched off to yield stable, isolable products or activated by specific physico-chemical stimuli, allowing the assemblies to adapt and respond to environmental changes in a controlled manner. This activatable dynamic property makes dynamic covalent assemblies particularly attractive for the design of complex matter, smart chemical systems, out-of-equilibrium systems, and molecular devices.

Graphical abstract: Dynamic covalent synthesis

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Article information

Article type
Review Article
09 Oct 2023
10 Dec 2023
First published
11 Dec 2023
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2024,15, 879-895

Dynamic covalent synthesis

F. B. L. Cougnon, A. R. Stefankiewicz and S. Ulrich, Chem. Sci., 2024, 15, 879 DOI: 10.1039/D3SC05343A

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