Ion carrier modulated MRI contrast†
Anna M.
Duncan, 
‡a
Connor M.
Ellis,
‡a
Aidan
Kerckhoffs,
a
Ferenc E.
Mózes,
b
Matthew J.
Langton
a
and
Jason J.
Davis
*a
‡a
Connor M.
Ellis,
‡a
Aidan
Kerckhoffs,
a
Ferenc E.
Mózes,
b
Matthew J.
Langton
a
and
Jason J.
Davis
*a
Abstract
An ion-responsive MRI contrast agent based on a POPC liposomal scaffold is generated that displays a large amplitude relaxivity switch. Entrapment of MR active Gd-DOTA within cholesterol-doped, i.e., membrane rigidified, liposomes dampens the MR response through diminished water exchange across the lipid bilayer. Relaxivity is re-established by integration of ion carriers in the liposome membrane to mediate solvated ion flux.
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