N,O-Reduction of 2,1-benzoisoxazoles in continuous flow is reported using copper hydride catalysis for the formation of 2-aminobenzophenones, key intermediates and cost drivers in the synthesis of benzodiazepines. In particular, ligand selection and precise control over reaction conditions allowed selective N,O- over 1,2-reduction.
C. Cavedon, S. J. Mear, A. Croke and T. F. Jamison, React. Chem. Eng., 2024, Advance Article , DOI: 10.1039/D3RE00538K
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