Metal free C–O bond cleavage: a new strategy for the synthesis of substituted oxazoles

Abstract

A strategy for the efficient metal-free C–O bond cleavage of ester using amines for the synthesis of substituted oxazoles was developed for the first time. The synthesis proceeded smoothly under metal-free conditions, combining C–O bond cleavage as well as C–N and C–O bond formation in one pot to yield desired products in moderate to excellent yields, and accommodated a wide range of functional groups and substrates.