Green mediated synthesis of cerium oxide nanoparticles by using Oroxylum indicum for evaluation of catalytic and biomedical activity

Abstract

The present perspective emphasizes the green synthesis of CeO₂-NPs using Oroxylum indicum fruit extract. The synthesized NPs were characterized utilizing analytical techniques, including FT-IR, UV-vis, XRD, SEM-EDX, and VSM. Of them, XRD analysis ratifies the cubic fluorite crystal structure along with a particle size of 23.58 nm. EDX results support the presence of cerium and oxygen in a proper ratio. The surface morphology of NPs, however, was scrutinized using SEM. The lower IC₅₀ value (20.8 μg mL⁻¹) of NPs compared to the reference substance, ascorbic acid (33.2 μg mL⁻¹), demonstrates CeO₂-NPs to be a compatible antioxidant. Moreover, the drug-releasing capability of CeO₂-NPs was a buffer pH-dependent parameter. The acidic pH solution was 20.5%, while the basic pH solution was 16.9%. The drug-releasing capability was analyzed using the Higuchi model and Korsmeyer–Peppas kinetics. The values of the determination coefficient (R²) were found to be 0.9944 and 0.9834, respectively. The photocatalytic activity of CeO₂-NPs was evaluated, considering methylene blue as a model dye. The degradation percentage was attained up to 56.77% after it had been exposed for 150 min. Apart from this, the synthesized NPs were screened against two fungus species, Bipolaris sorokiniana and Fusarium. The percentage of growth was measured at 56% and 49%, respectively.