Issue 34, 2024, Issue in Progress
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RSC Advances

2-Chloro-3-cyano-4-nitrobenzyl pyridinium bromide as a potent anti-lung cancer molecule prepared using a single-step solvent-free method†

Sadaiyan Govindaraj,a   Kilivelu Ganesan, ORCID logo *a   Perumal Elumalai,b   Rajanathadurai Jeevitha,b   Annadurai Subramani,c   Mohammed Amanullahd  and  Awad Saeed Al-Samghane  

* Corresponding authors

a PG& Research Department of Chemistry, Presidency College, Chennai 600005, India
E-mail: kiliveluganesan@yahoo.co.in

b Cancer Genomics lab, Center for Global Health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai 602105, India

c Department of Chemistry, Dwaraka Doss Goverdhan Doss Vaishnav College, Chennai 600106, India

d Department of Clinical Biochemistry, College of Medicine, King Khalid University, Abha 61413, Kingdom of Saudi Arabia

e Department of Family Medicine and Community Medicine, College of Medicine, King Khalid University, Abha, Kingdom of Saudi Arabia

Abstract

Mono-/dimeric-substituted pyridinium and pyrazolium bromides were prepared under conventional and solvent-free silica-supported domestic microwave conditions. The atom economy, environmental product mass intensity and product mass intensity for solvent-free reactions showed significant importance for the synthesis of target molecules. 4-Nitrobenzyl-substituted pyridinium bromide showed potent anticancer properties compared with mono-/dimeric-substituted pyridinium and pyrazolium bromides against a lung cancer cell line (A-549). Molecular simulation studies were carried out for mono-/dimeric-substituted pyridinium and pyrazolium bromide against protein human CDK1/cyclinB1/CKS2 using the AutoDock program.

Graphical abstract: 2-Chloro-3-cyano-4-nitrobenzyl pyridinium bromide as a potent anti-lung cancer molecule prepared using a single-step solvent-free method

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Article information

DOI
https://doi.org/10.1039/D4RA03538K
Article type
Paper
Submitted
14 May 2024
Accepted
11 Jul 2024
First published
08 Aug 2024
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2024,14, 24898-24909

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2-Chloro-3-cyano-4-nitrobenzyl pyridinium bromide as a potent anti-lung cancer molecule prepared using a single-step solvent-free method

S. Govindaraj, K. Ganesan, P. Elumalai, R. Jeevitha, A. Subramani, M. Amanullah and A. S. Al-Samghan, RSC Adv., 2024, 14, 24898 DOI: 10.1039/D4RA03538K

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