Issue 27, 2024, Issue in Progress

Topography hierarchy of biocompatible polyhydroxyalkanoate film

Abstract

Polyhydroxyalkanoates (PHAs) are used for various biomedical applications due to their biocompatibility. Surface properties, such as surface roughness, are crucial for PHAs performance. Traditional parameters used for the characterization of surface roughness, such as Ra, are often insufficient to capture the complex and hierarchical (multiscale) topography of PHA films. We measure the topography and surface roughness of thin PHA films with atomic force microscopy and analyze the topography data using several relatively novel data processing methods, including the calculation of autocorrelation functions, topological data analysis, and the distribution of minimum and maximum values of pixels over the topography data. The results provide details of multiscale and anisotropic surface properties that are crucial to PHAs biocompatibility but often overlooked by traditional topography analysis methods.

Graphical abstract: Topography hierarchy of biocompatible polyhydroxyalkanoate film

Supplementary files

Article information

Article type
Paper
Submitted
08 May 2024
Accepted
10 Jun 2024
First published
18 Jun 2024
This article is Open Access
Creative Commons BY license

RSC Adv., 2024,14, 19603-19611

Topography hierarchy of biocompatible polyhydroxyalkanoate film

F. D. E. Ghorabe, A. Aglikov, A. S. Novikov, M. Nosonovsky, G. A. Ryltseva, A. E. Dudaev, N. G. Menzianova, E. V. Skorb and E. I. Shishatskaya, RSC Adv., 2024, 14, 19603 DOI: 10.1039/D4RA03398A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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