Issue 28, 2024

Insights into the sustainability of liquid chromatographic methods for favipiravir bioanalysis: a comparative study

Abstract

The introduction of favipiravir as a broad-spectrum antiviral agent, particularly in treating influenza and exploring its potential against COVID-19, emphasizes the necessity for efficient analytical methods. Liquid chromatography has emerged as a commonly utilized technique for quantifying favipiravir in biological fluids. However, the environmental and health concerns linked to classical analytical methods mean a transition toward green analytical chemistry is required. This study investigates the environmental impact of 19 liquid chromatographic methods utilized in the bioanalysis of favipiravir. Recognizing the importance of eco-friendly practices in pharmaceutical analysis, the study employs three widely accepted greenness assessment tools: Analytical Eco-Scale (AES), Green Analytical Procedure Index (GAPI), and Analytical Greenness Calculator (AGREE). Moreover, it incorporates a comprehensive evaluation on a global scale utilizing the whiteness assessment tool Red-Green-Blue 12 (RGB 12). The comprehensive evaluation aims to extend beyond traditional validation criteria and considerations of green chemistry, providing insights into the development of practically efficient, eco-friendly and economical analytical methods for favipiravir determination. This study emphasizes the necessity of planning for the environmental impact and overall sustainability of analytical methods before laboratory trials. Additionally, the integration of greenness/whiteness evaluation in method validation protocols is strongly advocated, emphasizing the importance of critical and global evaluations in analytical chemistry.

Graphical abstract: Insights into the sustainability of liquid chromatographic methods for favipiravir bioanalysis: a comparative study

Supplementary files

Article information

Article type
Review Article
Submitted
23 Apr 2024
Accepted
13 Jun 2024
First published
18 Jun 2024
This article is Open Access
Creative Commons BY license

RSC Adv., 2024,14, 19658-19679

Insights into the sustainability of liquid chromatographic methods for favipiravir bioanalysis: a comparative study

A. Mostafa, RSC Adv., 2024, 14, 19658 DOI: 10.1039/D4RA03017F

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements