Discovery of new triterpene glycosides from Dendrobium officinale with their α-glucosidase and α-amylase inhibitory activity

Abstract

In this study, seven new pentacyclic triterpene glycosides, named dendrocinaosides A–G (1–7), and six known ones (8–13) were isolated from the whole plants of Dendrobium officinale. Their structures were determined by analyses of HR-ESI-MS, 1D and 2D NMR spectra. Compounds 1–4, 8, and 9 potentially inhibited α-glucosidase and α-amylase activities with the IC₅₀ values ranging from 31.3 ± 2.2 to 42.4 ± 2.5 μM for anti α-glucosidase and from 36.5 ± 1.8 to 56.4 ± 2.0 μM for anti α-amylase activities, respectively, which were lower than that of the positive control, acarbose, showing IC₅₀ values of 47.1 ± 1.4 μM for anti α-glucosidase and 145.7 ± 2.2 μM for anti α-amylase.