Multicomponent synthesis via acceptorless alcohol dehydrogenation: an easy access to tri-substituted pyridines

Abstract

Herein, we report palladium supported on a hydroxyapatite catalyst for synthesizing tri-substituted pyridines using ammonium acetate as the nitrogen source via acceptorless alcohol dehydrogenation strategy. The strategy offers a broad substrate scope using inexpensive and readily available alcohols as the starting material. The catalyst was prepared using a simple method and analyzed by several techniques, including FE-SEM, EDS, HR-TEM, BET, XRD, FT-IR, UV-visible spectroscopy, and XPS, demonstrating the anchoring of Pd nanoparticles on hydroxyapatite in the zero oxidation state. Moreover, several controlled experiments were carried out to understand the reaction pathway and a suitable mechanism has been proposed.