Issue 7, 2024, Issue in Progress

Modification of nanodiamonds for fluorescence bioimaging

Abstract

Non-invasive bioimaging is essential in enhancing pre-clinical diagnosis and therapy. Developing efficient imaging probes with high stability, low toxicity, and the potential of offering high resolution images is a very important aspect of developing non-invasive bioimaging techniques. Fluorescent nanodiamonds, which are produced by high energy beam irradiation and high temperature/pressure treatment, have been extensively investigated. In this study, we report the chemical modification of common nanodiamonds (prepared by detonation and high-pressure high-temperature milling) using a stable fluorophore (perylene diimide derivative) via carbodiimide coupling. The resulting nanodiamonds show good biocompatibility, cellular uptake and fluorescent imaging potential with mesenchymal stromal cells. This method provides an efficient alternative approach to the preparation and the use of fluorescent nanodiamonds for bioimaging, with the potential benefit of chemically adjusting the structure of perylene diimide for optimized emission/absorbance wavelength.

Graphical abstract: Modification of nanodiamonds for fluorescence bioimaging

Supplementary files

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Article information

Article type
Paper
Submitted
22 Dec 2023
Accepted
29 Jan 2024
First published
05 Feb 2024
This article is Open Access
Creative Commons BY license

RSC Adv., 2024,14, 4633-4644

Modification of nanodiamonds for fluorescence bioimaging

C. Fryer, P. Murray and H. Zhang, RSC Adv., 2024, 14, 4633 DOI: 10.1039/D3RA08762J

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