Bimetallic metal organic framework/Ni doped ZnO nanomaterials modified carbon paste electrode for selective electrochemical determination of ciprofloxacin

Abstract

In this work, an efficient and sensitive electrochemical sensor for the determination of ciprofloxacin (CIP) is reported. The sensor was prepared by using a carbon paste electrode (CPE) modified with a combination of bimetallic copper/cerium-based metal organic framework (Cu/Ce-MOF) and nickel doped zinc oxide nanoparticles (NZP). The modifiers were characterized by Brunauer–Emmett–Teller (BET) analysis, Fourier-transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), and elemental mapping analysis (EDS). The electrochemical behavior of the modified electrode was studied by electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). The developed electrode was employed for the detection of CIP by differential pulse voltammetry (DPV). Under optimal conditions, the anodic peak current response of the electrode was linearly correlated with CIP concentration in the range of 0.75–100 μmol L⁻¹ with a sensitivity of 1.29 μA μmol⁻¹ L⁻¹. The limit of detection and reproducibility of the method were 0.142 μmol L⁻¹ and 2.7%, respectively. The developed sensor showed good selectivity to CIP against possible interferents. The method was applied to determine CIP in water, milk and urine samples. The results indicated that this method has potential to be applied in the analysis of residue CIP in complex matrices with high selectivity, and good reproducibility.