Recent advances in the application of alkynes in multicomponent reactions

Abstract

Alkynes have two active positions to carry out chemical reactions: CC and C–H. These two positions are involved and activated in different reactions using different reagents. In this study, we investigated the reactions of alkynes that are involved in multi-component reactions through the C–C and C–H positions and examined the progress and gaps of each reaction by carefully studying the mechanism of the reactions. Firstly, we investigated and analyzed the reactions involving the CC position of alkynes, including the reactions between derivatives of alkynes with RN₃, sulfur compounds (RSO₂R′, DMSO, S₈, DABCO(SO₂)₂ and DABSO), barbituric acids, aldehydes and amines, COOH, α-diazoesters or ketones, and isocyanides. Then, we examined and analyzed the important reactions involving the C–H position of alkynes and the progress and gaps in these reactions, including the reaction between alkyne derivatives with amines and aldehydes for the synthesis of propargylamines, the reaction between alkynes with CO₂ and the reaction between alkynes with CO.