Issue 2, 2024, Issue in Progress

Unusual reactivity of 2,2-diphenyl-1-picrylhydrazyl (DPPH) with Fe3+ controlled by competing reactions

Abstract

2,2-Diphenyl-1-picrylhydrazyl (DPPH) is a stable organic free radical widely used in various fields as a model free radical. There is scarce information about the stability of this compound in the chemical environments in which it is used. Side reactions between DPPH and other species can alter the precision of experiments that use DPPH, such as the evaluation of antioxidant properties amongst others. Following recent investigations highlighting reactions between DPPH and metal cations or Lewis acids, a quantitative reaction between DPPH and Fe3+ in acetonitrile was studied in the present work. UV-Vis spectroscopy and electrochemistry were used to monitor the reaction. The results obtained indicate a fast and multistep reaction between Fe3+ and DPPH that can be simplified as a simple redox reaction with the formation of Fe2+ and DPPH+. The reaction mechanism proposed follows complex steps involving two competing phenomena: a disproportionation which accelerates the reaction and an oxidation process that slows it down through DPPH regeneration.

Graphical abstract: Unusual reactivity of 2,2-diphenyl-1-picrylhydrazyl (DPPH) with Fe3+ controlled by competing reactions

Supplementary files

Article information

Article type
Paper
Submitted
18 Oct 2023
Accepted
14 Dec 2023
First published
03 Jan 2024
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2024,14, 1354-1359

Unusual reactivity of 2,2-diphenyl-1-picrylhydrazyl (DPPH) with Fe3+ controlled by competing reactions

A. D. Djitieu Deutchoua, Y. Ngueumaleu, R. W. Liendji, S. S. Poungoue Hanga, B. B. Nguelo, G. K. Dedzo and E. Ngameni, RSC Adv., 2024, 14, 1354 DOI: 10.1039/D3RA07106E

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