Post-synthetic modified luminescent metal–organic framework for the detection of berberine hydrochloride in a traditional Chinese herb

Abstract

In this work, a novel fluorescence sensor UiO-66-PSM based on post-synthetic modified metal–organic frameworks was prepared for the detection of berberine hydrochloride (BBH) in the traditional Chinese herb Coptis. UiO-66-PSM was synthesized by a simple Schiff base reaction with UiO-66-NH₂ and phthalaldehyde (PAD). The luminescence quenching can be attributed to the photo-induced electron transfer process from the ligand of UiO-66-PSM to BBH. The UiO-66-PSM sensor exhibited fast response time, low detection limit, and high selectivity to BBH. Moreover, the UiO-66-PSM sensor was successfully applied to the quantitative detection of BBH in the traditional Chinese herb Coptis, and the detection results obtained from the as-fabricated fluorescence sensing assay were consistent with those of high-performance liquid chromatography (HPLC), indicating that this work has potential applicability for the detection of BBH in traditional Chinese herbs.