Electrochemical diversification of cysteine derivatives and cysteine-containing peptides to phosphorothioates and sulfinates

Abstract

This study explores the application of modified cysteine in oligopeptides to overcome challenges in amino acid residue modification, with a focus on cysteine. Novel strategies for the functionalization of biomolecules are presented, with mechanistic investigations indicating the involvement of free radical processes, structural substitution, and nucleophilic displacement. Notably, the gram-scale synthesis of modified cysteine is achieved with high yields, highlighting its potential as a novel anti-fungus agent in biomedical and agrochemical research.

Graphical abstract: Electrochemical diversification of cysteine derivatives and cysteine-containing peptides to phosphorothioates and sulfinates

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Article information

Article type
Research Article
Submitted
15 Aug 2024
Accepted
27 Sep 2024
First published
01 Oct 2024

Org. Chem. Front., 2024, Advance Article

Electrochemical diversification of cysteine derivatives and cysteine-containing peptides to phosphorothioates and sulfinates

L. Xiao, Y. Li, J. Huang, L. Pan, P. Wu and Y. Weng, Org. Chem. Front., 2024, Advance Article , DOI: 10.1039/D4QO01502A

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