BCl3 catalyzed Z-selective intramolecular chlorocarbamoylation of alkynes/allenes

Abstract

A metal-free stereoselective intramolecular chlorocarbamoylation of alkynes/allenes driven by BCl3 was described, which provides a general and practical method for constructing versatile and chlorinated methylene lactams or tetrahydroisoquinolinones with (Z) geometry at the double bond, featuring a stereochemically defined tetrasubstituted chloroethene.

Graphical abstract: BCl3 catalyzed Z-selective intramolecular chlorocarbamoylation of alkynes/allenes

Supplementary files

Article information

Article type
Research Article
Submitted
13 Aug 2024
Accepted
26 Sep 2024
First published
28 Sep 2024

Org. Chem. Front., 2024, Advance Article

BCl3 catalyzed Z-selective intramolecular chlorocarbamoylation of alkynes/allenes

Z. Yang, L. Chen, Y. Zhao, Q. Chen, W. Zhao, L. Li, B. Zhang, H. Xie, X. Kong and C. Yang, Org. Chem. Front., 2024, Advance Article , DOI: 10.1039/D4QO01487A

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