Non-Kolbe oxidation driven electrochemical C(sp2)–H lactonization towards the synthesis of isocoumarins

Abstract

A novel method for electrochemical C(sp2)–H lactonization was developed. This strategy enabled the synthesis of various isocoumarins in moderate to excellent yields with good functional group tolerance. The gram-scale reaction and derivatizations of the product showed the applicability of this method. Relevant mechanism experiments supported the rare non-Kolbe process. Overall, this work provides a sustainable and cheaper approach for the synthesis of isocoumarins.

Graphical abstract: Non-Kolbe oxidation driven electrochemical C(sp2)–H lactonization towards the synthesis of isocoumarins

Supplementary files

Article information

Article type
Research Article
Submitted
27 Jul 2024
Accepted
29 Sep 2024
First published
30 Sep 2024

Org. Chem. Front., 2024, Advance Article

Non-Kolbe oxidation driven electrochemical C(sp2)–H lactonization towards the synthesis of isocoumarins

C. Liu, H. Liu, G. Zhang, Y. Liu, P. Liao, Y. Mei and Y. Zhang, Org. Chem. Front., 2024, Advance Article , DOI: 10.1039/D4QO01381F

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