Issue 17, 2024

Divergent pentafluoroethylation of styrene derivatives using CuCF2CF3

Abstract

A series of pentafluoroethylation reactions of styrene derivatives are described using the [CuCF2CF3] reagent prepared from low-cost pentafluoroethane (HCF2CF3). Under aerobic conditions, chloropentafluoroethylation, dimerization-pentafluoroethylation, vinylic pentafluoroethylation, formyloxylation-pentafluoroethylation and hydroxypentafluoroethylation can be achieved using styrenes to generate various functionalized products containing the CF2CF3 group. It is remarkable that a single reagent is capable of such divergent reactivities with readily available feedstocks.

Graphical abstract: Divergent pentafluoroethylation of styrene derivatives using CuCF2CF3

Supplementary files

Article information

Article type
Research Article
Submitted
29 Apr 2024
Accepted
23 Jun 2024
First published
25 Jun 2024

Org. Chem. Front., 2024,11, 4697-4701

Divergent pentafluoroethylation of styrene derivatives using CuCF2CF3

Z. Fu and G. C. Tsui, Org. Chem. Front., 2024, 11, 4697 DOI: 10.1039/D4QO00768A

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