Issue 13, 2024

Synthesis of heteroaryl C-glycosides via Ru-catalyzed C–H activation/cyclization: dioxazolone glycogen designs and applications

Abstract

New glycogen reagents of dioxazolone glycogen anomers have been developed. The versatile heteroarene C-glycosides have been synthesized using a Ru-catalyzed C–H activation/annulation strategy, employing these dioxazolone glycogen anomers. These reactions tolerate various saccharide donors and enable stereoselective synthesis of heterocyclic C-glycosides. The strategy and methods were well applicable to a large-scale reaction and late-stage modification of structurally complex natural products.

Graphical abstract: Synthesis of heteroaryl C-glycosides via Ru-catalyzed C–H activation/cyclization: dioxazolone glycogen designs and applications

Supplementary files

Article information

Article type
Research Article
Submitted
22 Mar 2024
Accepted
10 May 2024
First published
13 May 2024

Org. Chem. Front., 2024,11, 3609-3613

Synthesis of heteroaryl C-glycosides via Ru-catalyzed C–H activation/cyclization: dioxazolone glycogen designs and applications

D. Liu, P. Wang, X. Hu, Y. Ruan, X. Wang, M. Wen, C. Zhang, Y. Xiao and X. Liu, Org. Chem. Front., 2024, 11, 3609 DOI: 10.1039/D4QO00529E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements