Synthesis of enantiopure 1,2,3-triazolylidene-type mesoionic carbene (MIC) conjugate acids featuring a rigid bicyclic scaffold

Abstract

Chiral NHCs have found numerous applications as ligands for transition metals and in their own right for asymmetric catalysis. Here, we report a synthetic route from L-malic acid to enantiopure 1,2,3-triazoliums (mesoionic carbene conjugate acids) with a chiral center in a fused ring.