An electrochemical multicomponent cascade annulation and functionalization reaction to enable C(sp3)–H trifluoromethylation

Abstract

Herein, we describe a novel electrochemistry facilitated one-pot multicomponent cascade annulation and bi-functionalization reaction that enables the efficient synthesis of highly functionalized 3,4-dihydroquinazolinones from readily available starting materials, realizing indirect C(sp³)–H trifluoromethylation of aromatic ketones. This methodology achieves two goals in one simple reaction, the direct synthesis of quinazolinones and the concurrent introduction of functional groups. This transformation has good compatibility with common functional groups and the scale-up electrolysis can be easily performed.