Issue 2, 2024

Electrochemical (radio)-halodesilylation of aromatic silanes

Abstract

We have developed a green and efficient electrochemical halodesilylation of trimethylsilanes to synthesize aryl halides. The reaction was carried out under mild conditions without sophisticated equipment, transition metal catalysts, hazardous oxidants, and additional electrolytes. The protocol also has broad substrate scope and high functional group tolerance. Moreover, this electrochemical method is applicable to radioactive iodine labeling.

Graphical abstract: Electrochemical (radio)-halodesilylation of aromatic silanes

Supplementary files

Article information

Article type
Research Article
Submitted
21 Sep 2023
Accepted
23 Nov 2023
First published
24 Nov 2023

Org. Chem. Front., 2024,11, 407-413

Electrochemical (radio)-halodesilylation of aromatic silanes

K. Gong, L. Lin, X. Gao, X. Zeng, B. Xu and J. Han, Org. Chem. Front., 2024, 11, 407 DOI: 10.1039/D3QO01553J

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