Issue 15, 2024

225Ac/213Bi radionuclide generators for the separation of 213Bi towards clinical demands

Abstract

Bismuth-213 (213Bi) is a promising radionuclide for clinical application in targeted alpha therapy of cancers. 225Ac/213Bi radionuclide generators are of particular interest for the production/separation of 213Bi. This review aims to give an overview of the current status of 225Ac production, 225Ac/213Bi radionuclide generator systems, the types of adsorbents, separation conditions, separation mechanisms, and critical challenges. The review also provides guidance for investigating emerging new sorbents that can be developed to overcome the limitations of currently used sorbents.

Graphical abstract: 225Ac/213Bi radionuclide generators for the separation of 213Bi towards clinical demands

Article information

Article type
Review Article
Submitted
02 Feb 2024
Accepted
05 May 2024
First published
10 Jun 2024
This article is Open Access
Creative Commons BY-NC license

Inorg. Chem. Front., 2024,11, 4499-4527

225Ac/213Bi radionuclide generators for the separation of 213Bi towards clinical demands

H. Zhu, S. Heinitz, K. Binnemans, S. Mullens and T. Cardinaels, Inorg. Chem. Front., 2024, 11, 4499 DOI: 10.1039/D4QI00326H

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