Well-defined cobalt(ii)-catalyzed synthesis of perimidine derivatives via acceptorless dehydrogenative annulation

Abstract

The versatility of the perimidine moiety offers a rich playground for researchers in fields ranging from medical science to industrial chemistry. Herein, we describe the first Co-catalyzed synthesis of 2,3-dihydro-1H-perimidine via acceptorless dehydrogenative annulation (ADA). Apart from featuring benzyl alcohol having different functionalities, heteroaryl and aliphatic alcohols also provide good yields. Our catalytic protocol is also suitable for different fatty alcohols for furnishing perimidine derivatives, keeping distal unsaturation intact. Several kinetic and control tests were carried out in order to understand the reaction sequence.

Graphical abstract: Well-defined cobalt(ii)-catalyzed synthesis of perimidine derivatives via acceptorless dehydrogenative annulation

Supplementary files

Article information

Article type
Communication
Submitted
06 Aug 2024
Accepted
02 Oct 2024
First published
03 Oct 2024

Org. Biomol. Chem., 2024, Advance Article

Well-defined cobalt(II)-catalyzed synthesis of perimidine derivatives via acceptorless dehydrogenative annulation

D. Pal, R. Sarmah, A. Mondal, I. Mallick and D. Srimani, Org. Biomol. Chem., 2024, Advance Article , DOI: 10.1039/D4OB01306A

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