Pyrazole based palladacycles for the synthesis of β-aminoketones by redox coupling of allyl alcohols and anilines

Abstract

Herein, we report the synthesis of β-aminoketones by oxidative coupling of allyl alcohols at room temperature using a pyrazole based palladacycle and BINOL-phosphoric acid system. This method avoids the use of any base, external oxidant, and additive. The reaction of p-anisidine and 1-penten-3-ol under the optimized conditions using isolated palladacycle–BINOL-phosphoric acid produced the desired product in 24 h, which suggests that the active species involved in this reaction is the palladacycle–BINOL-phosphoric acid.