Ag-Catalyzed cross-dehydrogenative-coupling for the synthesis of 1,4-dioxan-2-yl substituted quinazoline hybrids in an aqueous medium

Abstract

We herein developed an effective approach for the construction of 2- or 4-(1,4-dioxan-2-yl) substituted quinazolines under mild conditions. A silver–K₂S₂O₈ catalyzed direct CDC reaction between quinazolines and 1,4-dioxane for the synthesis of a series of 2- or 4-(1,4-dioxan-2-yl) substituted quinazoline hybrids is reported. The reaction proceeded well in water under mild conditions and showed a broad substrate scope and good functional group compatibility.