Issue 44, 2024

Propargyl alcohol as an acrolein equivalent: synthesis of β-(3-indolyl)acroleins and β-(imidazo[1,2-a]pyridin-3-yl)acroleins

Abstract

A simple and straightforward method has been developed to access distinctly substituted β-(3-indolyl)acroleins and β-(imidazo[1,2-a]pyridin-3-yl)acroleins using propargyl alcohol as an acrolein equivalent. A broad substrate scope, good yields, easily accessible substrates, and metal-free conditions are the salient features of the developed methodology. This work contributes to a significant advancement in the sustainable synthesis of functionalized acroleins.

Graphical abstract: Propargyl alcohol as an acrolein equivalent: synthesis of β-(3-indolyl)acroleins and β-(imidazo[1,2-a]pyridin-3-yl)acroleins

Supplementary files

Article information

Article type
Communication
Submitted
14 Jul 2024
Accepted
20 Sep 2024
First published
24 Sep 2024
This article is Open Access
Creative Commons BY license

Org. Biomol. Chem., 2024,22, 8720-8723

Propargyl alcohol as an acrolein equivalent: synthesis of β-(3-indolyl)acroleins and β-(imidazo[1,2-a]pyridin-3-yl)acroleins

Bhawani, Sonam, V. N. Shinde, P. N. Swami, K. Rangan and A. Kumar, Org. Biomol. Chem., 2024, 22, 8720 DOI: 10.1039/D4OB01168F

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