Halogenation of aromatic compounds with N-halosuccinimides (NXS) catalysed by d-camphorsulfonic acid-BiCl3

Abstract

Aromatic bromination catalysed by 0.5–10 mol% of D-camphorsulfonic acid-BiCl3 with N-bromosuccinimides (NBS) was carried out in MeCN under air conditions, and the procedure was extended to the reactions with N-chlorosuccinimides (NCS) and N-iodosuccinimides (NIS). The halogenation of some drugs and natural products was also attempted. One-pot bromination/Suzuki–Miyaura cross-coupling and bromination/Sonogashira coupling reactions were achieved without the removal of the solvent.