Issue 34, 2024

Iron-catalyzed synthesis of substituted 3-arylquinolin-2(1H)-ones via an intramolecular dehydrogenative coupling of amido-alcohols

Abstract

Here we report an iron-complex-catalyzed synthesis of various mono- and di-substituted quinolin-2(1H)-ones achieved via the intramolecular acceptorless dehydrogenative cyclization of amido-alcohols. This approach for the synthesis of N-heterocycles has provided access to underdescribed disubstituted quinolinones and represents an alternative to the well-known palladium-catalyzed coupling reactions.

Graphical abstract: Iron-catalyzed synthesis of substituted 3-arylquinolin-2(1H)-ones via an intramolecular dehydrogenative coupling of amido-alcohols

Supplementary files

Article information

Article type
Communication
Submitted
22 Apr 2024
Accepted
24 Jul 2024
First published
26 Jul 2024

Org. Biomol. Chem., 2024,22, 6933-6940

Iron-catalyzed synthesis of substituted 3-arylquinolin-2(1H)-ones via an intramolecular dehydrogenative coupling of amido-alcohols

L. Bettoni, N. Joly, I. Mendas, M. M. Moscogiuri, J. Lohier, S. Gaillard, A. Poater and J. Renaud, Org. Biomol. Chem., 2024, 22, 6933 DOI: 10.1039/D4OB00649F

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